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Depakote Sprinkle® capsules: Swallow total or sprinkle on to food items, for instance applesauce or pudding and take in immediately. Don't chew the sprinkle capsule or contents.
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There exists an increased possibility of valproate-induced acute liver failure and resultant deaths in individuals with hereditary neurometabolic syndromes a result of DNA mutations of the mitochondrial DNA Polymerase γ (POLG) gene (e.g. Alpers Huttenlocher Syndrome). Depakote is contraindicated in patients recognized to have mitochondrial disorders caused by POLG mutations and youngsters less than two a long time of age who're clinically suspected of having a mitochondrial ailment [see CONTRAINDICATIONS].
are allergic to divalproex sodium, valproic acid, sodium valproate, or any of the components in Depakote. See the conclusion of this Medication Guidebook for a whole list of components in Depakote. Possess a genetic issue termed a urea cycle condition.
Concurrent use of valproate and amitriptyline has rarely been connected with toxicity. Monitoring of amitriptyline ranges ought to be deemed for individuals taking valproate concomitantly with amitriptyline. Consideration ought to be provided to decreasing the dose of amitriptyline/nortriptyline while in the existence of valproate.
Therefore, checking of total serum valproate are not able to provide a reputable index of the bioactive valproate species.
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With regards to breastfeeding, caution is encouraged considering the fact that valproate does go into breast milk in modest quantities.
Tend not to give Depakote to other people, regardless of whether they've got the same signs or symptoms that you have. It could harm them. You may inquire your pharmacist or Health care service provider for details about Depakote that is definitely written for wellness industry experts.
Depakote will not be recommended for use in the course of pregnancy; it might damage a fetus. Girls really should communicate for their physician about making use of contraception although using Depakote. Talk to your medical professional before breastfeeding.
Depakote (divalproex sodium) can be a valproate and it is indicated with the treatment method from the manic episodes affiliated with bipolar dysfunction. A manic episode is a distinct duration of abnormally and persistently elevated, expansive, or irritable temper.
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It can be crucial to abide by up with the medical professional for blood operate and to Get hold of your medical professional instantly when you observe abdominal pain, sudden nausea or vomiting, or improvements in temper or behavior.